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Michael Stickland, PhD
ASSISTANT PROFESSOR
CIHR
New Investigator
Division
of Pulmonary Medicine,
Department
of Medicine
2E4.42 Walter C Mackenzie Health
Sciences Centre
University
of Alberta
Tel:
780.407.7845
Fax:
780.407.6384
michael.stickland@ualberta.ca
Education
PDF – University of Wisconsin – MadisonPhD – University of Alberta
BPE – University of Alberta
Research Interests
I am interested in examining cardiopulmonary physiology in health and disease. Specifically I am interested in three areas:1. Chemoreceptor control of cardiovascular function in health and disease.
Previous work has shown that stimulation of the carotid chemoreceptor increases sympathetic vasoconstrictor outflow. Conditions such as chronic heart failure are characterized by enhanced chemosensitivity which can contribute to exertional dyspnea, and chemosensitivity has been shown to be predictive of survival in heart failure patients. We have shown in animals that the carotid chemoreceptor contributes to the sympathetic restraint of blood flow in heart failure as well as during exercise in both health and heart failure. More recently we have demonstrated that the carotid chemoreceptor contributes to the increased muscle sympathetic outflow during exercise in health. Future studies are designed to further translate these finding to the human by examining patients with heart failure as well as chronic lung disease patients.2. Pulmonary Rehabilitation
As Research Director of the Caritas Centre for Lung Health, which runs the primary Pulmonary Rehabilitation program in Edmonton, I am interested in health outcomes from Pulmonary Rehab. Currently, studies are underway investigating how co-morbidities such as cardiovascular disease impact health outcomes from rehab. Future work will examine how to better maintain health outcomes in the months following rehab.3. Intra-Pulmonary Arterio-venous Shunt and Pulmonary Gas Exchange.
We have shown that exercise recruits intra-pulmonary arterio-venous shunts which appear to contribute to the impairment in gas exchange observed with exercise. We have found these shunts to be greater that 50um in isolated human lungs, and greater than 25um in exercising animals. Future studies will examine the mechanisms which recruit these shunts, and their physiological consequence.Highlighted Publications
Stickland M.K., Miller J.D. The best medicine: exercise training normalizes chemosensitivity and sympathoexcitation in heart failure. Journal of Applied Physiology 105: 779-781, 2008.Stickland M.K., Morgan B.J., Dempsey J.A. Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans. Journal of Physiology, 586: 1743-1754, 2008.
Stickland M.K., Lovering A.T., and Eldridge M.W. Exercise-induced Arteriovenous Intra-Pulmonary Shunting in Dogs. American Journal of Respiratory and Critical Care Medicine, 176: 300-305, 2007.
Stickland, M.K., Miller, J.D., Smith, C.A., Dempsey, J.A. Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure. Circulation Research, 100: 1371-8, 2007.
Lovering A.T., Stickland M.K., Kelso A.J., Eldridge M.W. Direct demonstration of 25 and 50 m arteriovenous pathways in healthy Human and Baboon lungs. American Journal of Physiology – Heart and Circulatory Physiology, 292: H1777-8, 2007.
Stickland, M.K., Lovering, A.T. Exercise-Induced Intra-Pulmonary Arteriovenous Shunting and Pulmonary Gas Exchange. Invited review for Exercise Sport Science Reviews 34:99-106, 2006
Stickland, M.K., Welsh, R.C., Haykowsky, M.J., Petersen, S.R., Anderson, W.D., Taylor, D.A., Bouffard, M., Jones, R.L. Effect of Acute Increases in Pulmonary Vascular Pressures on Exercise Pulmonary Gas Exchange. Journal of Applied Physiology, 100: 1910-1917, 2006.
Stickland, M.K., Welsh, R.C., Petersen, S.R., Tyberg, J.V., Anderson, W.D., Jones, R.L., Taylor, D.A., Bouffard, M., Haykowsky, M.J. Does fitness level modulate the cardiovascular hemodynamic response to exercise? Journal of Applied Physiology, 100: 1895-1901, 2006.
Stickland, M.K., Welsh, R.C., Haykowsky, M.J., Petersen, S.R., Anderson, W.D., Taylor, D.A., Bouffard, M., Jones, R.L. Intra-Pulmonary Shunt and Pulmonary Gas Exchange During Exercise in Humans. Journal of Physiology, 561: 321-329, 2004.
Funding:
CIHR New InvestigatorAlberta Lung Association
